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JPH203 (Synonyms:O-[(5-氨基-2-苯基-7-苯并恶唑基)甲基]-3,5-二氯-L-酪氨酸)
目录号 : KCM10135 CAS No. : 1037592-40-7 纯度 : ≥98%
Data Sheet 产品使用指南
JPH203 is an inhibitor of L-type amino acid transporter 1 (LAT1; IC = 0.14 μM for C-leucine uptake in S2 cells expressing the human transporter). It is selective for LAT1 over LAT2 (IC = >10 μM). JPH203 inhibits C-leucine uptake by, and growth of, HT-29 cells (ICs = 0.06 and 4.1 μM, respectively). It induces apoptosis and increases levels of cleaved caspase-3, caspase-7, caspase-9, and poly(ADP-ribose) polymerase (PARP) in YD-38 oral cancer cells when used at a concentration of 3 mM. JPH203 (6.3, 12.5, and 25 mg/kg) reduces tumor growth in an HT-29 mouse xenograft model.
规格 价格 是否有货 数量
1mg
In-stock
5mg
In-stock
10mg
In-stock
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分子式
C23H19Cl2N3O4
分子量
472.32018
CAS号
1037592-40-7
中文名称
Unii-cedo9qxyzk
储存方式
-20°C
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