KKL 顾客使用本产品发表的 1 篇科研文献

CGP52432 is a GABA_B receptor antagonist, with an IC₅₀ of 85 nM.

CGP52432 is a GABA_B receptor antagonist, with an IC₅₀ of 85 nM, 35- and 100-fold lower than at the receptors regulating somatostatin and glutamate overflow, respectively.

CGP52432 (10, 30 mg/kg) shows no effect on the total arm entries and total head dips of mice on the elevated-plus maze. CGP52432 (100 nmol/kg, i.v., or 1 nmol/kg, i.c.v.) abolishes the suppressive effects of GABA ( 50 μmol/kg, i.v.) on enhanced renal sympathetic nerve activity (RSNA) during ischaemia, causeing elimination of the renoprotective effects of GABA in rats.

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