N-Arachidonylglycine (Synonyms:NA-Gly)
目录号 : KM5383 CAS No. : 179113-91-8 纯度 : ≥98%

N-Arachidonylglycine (NA-Gly) 是内源性大麻素类 anandamide (AEA) 的羧基类似物,是一种 GPR18 激动剂 (EC50 = 44.5 nM)。与 AEA 不同,N-Arachidonylglycine 在 CB1 和 CB2 受体上均无活性。N-Arachidonylglycine 可抑制 GLYT2 (IC50 = 5.1 μM)。 N-Arachidonylglycine 也是子宫内膜细胞迁移的有效激活剂。

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生物活性

N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration.

体外研究

N-Arachidonylglycine (0.1 nM-100 µM; 5 min) drives MAPK activation in GPR18-transfected HEK293 cells.
N-Arachidonylglycine shows no activity at GLYT1 or GAT1 at concentrations up to 100 μm.

Western Blot Analysis

Cell Line: HEK293-GPR18 cells
Concentration: 0.1 nM-100 µM
Incubation Time: 5 min
Result: Drove MAPK activation.
体内研究

N-Arachidonylglycine (10 mg/kg; oral) increases blood concentrations of anandamide 9-fold.
N-Arachidonylglycine (1.2 mg/kg; oral; once) results in a significant 70% reduction of peritoneal cells.

Animal Model: Rats
Dosage: 10 mg/kg
Administration: Oral
Result: Inhibition of FAAH, causing a reduction in the hydrolytic cleavage of anandamid.
Animal Model: Mouse (peritonitis model)
Dosage: 1.2 mg/kg
Administration: Oral; once
Result: Resulted in a significant 70% reduction of peritoneal cells.
分子式
C22H35NO3
分子量
361.52
CAS号
179113-91-8
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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