Diclofenac Sodium - CAS:15307-79-6

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Diclofenac Sodium (Synonyms:双氯芬酸钠; GP 45840)

目录号 : KM5216 CAS No. : 15307-79-6 纯度 : 98%

Data Sheet 产品使用指南

Diclofenac Sodium (GP 45840) 是一种有效的，非选择性抗炎剂，为 COX 的抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的 IC₅₀ 值分别为 4 和 1.3 nM。Diclofenac Sodium 对绵羊 COX-1 和 COX-2 的 IC₅₀ 值分别为 5.1 μM，0.84 μM。Diclofenac Sodium 通过活化 caspase 级联反应来诱导神经干细胞凋亡 (apoptosis)。

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5g		In-stock
10g	询价	In-stock
50g	询价	In-stock

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生物活性

Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

体外研究

Diclofenac effectively blocks COX-1 mediated prostanoid production from U937 cell microsomes, with an IC₅₀ of 7±3 nM.
Diclofenac (1-60 μM; 1 day) induces neural stem cells (NSCs)death in a concentration-dependent manner.
Diclofenac (10-60 μM; 6 hours) increases the expression of cleaved (activated) caspase-3.

Cell Viability Assay

Cell Line:	Neural stem cells (NSCs)
Concentration:	1, 3, 10, 30, 60 μM
Incubation Time:	1 day
Result:	Induction of cell death was concentration-dependent and the effect was not saturated at a concentration of up to 60 μM.

Western Blot Analysis

Cell Line:	Neural stem cells (NSCs)
Concentration:	10, 30 or 60 μM
Incubation Time:	6 hours
Result:	The activation of caspase-3 was increased in a concentration-dependent manner.

体内研究

Diclofenac (3 mg/kg, b.i.d., for 5 days) significantly increases faecal Cr excretion in rats, and such effect is also observed in squirrel monkeys after administrated of 1 mg/kg twice daily for 4 days.
Diclofenac (10 mg/kg; administered via oral route just prior to induction of inflammation) shows in vivo anti-inflammatory activity in Wistar rats.

Animal Model:	Male Sprague-Dawley rats (150±200 g)
Dosage:	3 mg/kg
Administration:	Oral administration, b.i.d., for 5 days
Result:	Resulted in a significant increase in faecal Cr excretion.

Animal Model:	Wistar rats (150-175 g) bearing Formalin-induced rat foot paw edema model
Dosage:	10 mg/kg
Administration:	Administered via oral route just prior to induction of inflammation
Result:	Showed in vivo anti-inflammatory activity (% edema inhibition=29.2, 1 h; 22.2, 3 h; 20, 6 h).

分子式

C₁₄H₁₀Cl₂NNaO₂

分子量

318.13

CAS号

15307-79-6

中文名称

双氯芬酸钠

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 10 mg/mL (31.43 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1434 mL	15.7168 mL	31.4337 mL
5 mM	0.6287 mL	3.1434 mL	6.2867 mL
10 mM	0.3143 mL	1.5717 mL	3.1434 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

临床试验

科研文献

纯度： 98%

Data Sheet

产品使用指南

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Other Forms of Rapamycin:

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