Surfactin - CAS:252023-70-4

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Surfactin

目录号 : KM4777 CAS No. : 252023-70-4 纯度 : ≥98%

Data Sheet 产品使用指南

Surfactin 是一种环状脂肽生物表面活性剂，由四种异构体（Surfactin A，B，C 和 D）组成，可介导单价和二价阳离子 (如钙离子) 穿过脂质双层膜的通量。Surfactin 可以作为抗微生物佐剂，具有抗菌，抗真菌，抗支原体和溶血作用。Surfactin 还对多种包膜病毒具有抗病毒活性。

规格	价格	是否有货
10mg		In-stock
50mg		In-stock
100mg	询价	In-stock
200mg	询价	In-stock

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生物活性

Surfactin is a potent cyclic lipopeptide biosurfactants consists of four isomers (Surfactin A, B, C and D), which mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes. Surfactin can act as an antimicrobial adjuvant with anti-bacterial, anti-fungal, antimycoplasma and hemolytic effects. Surfactin also has antiviral activity against a variety of enveloped viruses.

体外研究

Surfactin can increase the activity of NSC277174 against avian pathogenic Escherichia coli (APEC) in vitro with antimicrobial assays such as minimum inhibitory concentrations (MIC) and fractional inhibitory concentration (FIC). For APEC O78 strain, the MIC of NSC277174 and Surfactin are 1000 ug/ml and >1mg/ml, respectively.

体内研究

In the model of chick infection (inoculation of E.coli), Surfactin exerts adjuvant effects with NSC277174 against APEC by lowering the numerical value of mortality and liver bacterial loads, and regulating the expression of inflammatory cytokines et al. Surfactin can act as a novel antimicrobial adjuvant with NSC277174 against AEPC infection in chicken.

分子式

C₅₃H₉₃N₇O₁₃

分子量

1025.04(Average)

CAS号

252023-70-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 50 mg/mL (Need ultrasonic)

H₂O : 31.25 mg/mL (Need ultrasonic)

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 110 mg/mL (Infinity mM); Clear solution; Need ultrasonic
2.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (Infinity mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (Infinity mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
3.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (Infinity mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (Infinity mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
4.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (Infinity mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (Infinity mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。