MK0343 (MRK-409) 是一种口服生物可利用的 GABAA 受体亚型选择性部分激动剂。MK0343 是一种非镇静的抗焦虑药物。
| 生物活性 |
MK0343 (MRK-409) is an orally bioavailable GABAA receptor subtype-selective partial agonist. MK0343 is a non-sedating anxiolytic. |
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| 体内研究 |
MK0343 readily penetrates the brain in rats and occupies the benzodiazepine site of GABAA receptors, measured using an in vivo [H]flumazenil binding assay, with an Occ50 of 2.2 mg/kg p.o. and a corresponding plasma EC50 of 115 ng/mL.
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| 分子式 |
C19H17F2N7O
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| 分子量 |
397.38
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| CAS号 |
233275-76-8
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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纯度： 98%
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