C8-Ceramide - CAS:74713-59-0

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C8-Ceramide (Synonyms:N-辛酰基-D-神经鞘氨醇; N-Octanoyl-D-erythro-sphingosine)

目录号 : KM4076 CAS No. : 74713-59-0 纯度 : ≥98%

Data Sheet 产品使用指南

C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) 是一种细胞渗透性的内源性神经酰胺类似物。C8-Ceramide 具有具有抗增殖特性，能作为化疗试剂。C8-Ceramide 能刺激树突状细胞促进 T 细胞对病毒感染的反应。C8-Ceramide 在体外能轻微地诱导 PKC 活化。

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5mg		In-stock
10mg	询价	In-stock
50mg	询价	In-stock

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生物活性

C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro.

体外研究

C8-ceramide (3 μM; 48 hours) irreversibly reduces tumor-cell proliferation and induces morphological changes.
C8-ceramide can induce necrosis-like cell death, but does not induce caspase-dependent cleavage of PARP (biochemical marker of apoptosis) in human cervical tumor cells.
C8-ceramide may increase the endogenous ROS level (10-30 µM; 24 hours) by regulating the switch of SOD1 and SOD2, causing the anti-proliferation (10-50 µM; 24 hours), and consequently triggering the apoptosis (10-50 µM; 48 hours) of NSCLC H1299 cells.

Cell Viability Assay

Cell Line:	CALO cells, INBL cells, HeLa cells
Concentration:	3 μM
Incubation Time:	48 hours
Result:	Markedly reduced the tumor cell number.

Cell Proliferation Assay

Cell Line:	H1299 cells
Concentration:	10 µM, 20 µM, 30 µM, 40 µM, 50 µM
Incubation Time:	24 hours
Result:	Decreased the rate of cellular proliferation in a dose-dependent manner, with an IC₅₀ of 22.9 µM.

Cell Cycle Analysis

Cell Line:	H1299 cells
Concentration:	10 µM, 20 µM, 30 µM, 40 µM, 50 µM
Incubation Time:	24 hours
Result:	Caused the G1 arrest.

Apoptosis Analysis

Cell Line:	H1299 cells
Concentration:	10 µM, 20 µM, 30 µM
Incubation Time:	24 hours, 48 hours
Result:	Increased the level of cleaved caspase-3.

体内研究

C8-ceramide (0.1 mg/kg; intranasal administration) induces more robust CD8 and CD4 T cell responses to viral infections in virus infected mice.

Animal Model:	C57BL/6 mice, with lymphocytic choriomeningitis virus infected
Dosage:	0.1 mg/kg
Administration:	Intranasal administration
Result:	Increased the CD8 T cell response to influenza in the lungs.

分子式

C₂₆H₅₁NO₃

分子量

425.69

CAS号

74713-59-0

中文名称

N-辛酰基-D-神经鞘氨醇

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

纯度： ≥98%

Data Sheet

产品使用指南

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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