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OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC₅₀ value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1.

OGG1-IN-08 (50 μM) inhibits different DNA glycosylases activities, it inhibits nei endonuclease VIII-like 1 DNA glycosylase (NEIL1)(84.56%), endonuclease III-like (NTH1)(63.09%), and Fpg (91.74%), respectively.
OGG1-IN-08 (10 μM) has a inhibitory OGG1 lyase activity on a substrate containing an AP site compared with the no inhibitor control.
OGG1-IN-08 (10 μM) decreases the number of bases released into solution by OGG1 for both the 8-oxo-Gua and FapyGua compared with the no inhibitor.

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