Synaptamide - CAS:162758-94-3

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Synaptamide (Synonyms:Dehydroepiandrosteron(DHEA; Docosahexaenoyl ethanolamide))

目录号 : KM3670 CAS No. : 162758-94-3 纯度 : ≥98%

Data Sheet 产品使用指南

Synaptamide (Dehydroepiandrosteron; DHEA) 是一种内源性代谢物，是 Anandamide 的结构类似物。Synaptamide 与大麻素-1 和 2 (CB1 和 CB2) 大麻素受体结合并具有抗炎特性。Synaptamide 第一个粘附 G 蛋白偶联受体 (aGPCR) 的小分子内源性配体。

规格	价格	是否有货	数量
5mg		In-stock
10mg		In-stock

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生物活性

Synaptamide (Dehydroepiandrosteron; DHEA) is an endogenous metabolite and structural analogue of Anandamide. Synaptamide binds to both the cannabinoid-1 and 2 (CB1 and CB2) cannabinoid receptors and has anti-inflammatory properties. Synaptamide is the first small-molecule endogenous ligand of an adhesion G protein-coupled receptor (aGPCR) .

体外研究

Synaptamide (Dehydroepiandrosteron; DHEA) is a weak agonist at both CB1 and CB2 receptors.

体内研究

Synaptamide (10 mg/kg; subcutaneously; daily for 7 days) promotes cognitive recovery in rats subjected to mild traumatic brain injury (mTBI).
Synaptamide (2-10 mg/kg; adult male C57BL/6J mice) reduced the levels of nociceptive and inflammatory pain-related behaviour over 60 min in the intraplantar formaldehyde assay via both intraperitoneal and local intraplantar administration.

Animal Model:	Male Wistar rats;260 ± 20 g, age 3 months; mTBI model)
Dosage:	10 mg/kg
Administration:	Subcutaneously; daily for 7 days
Result:	Reversed the mTBI-induced cognitive deficits.

分子式

C₂₄H₃₇NO₂

分子量

371.56

CAS号

162758-94-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years

溶解性数据

In Vitro:

Ethanol : 25 mg/mL (67.28 mM; Need ultrasonic)

科研文献

•Ecotoxicol Environ Saf. 2021 Feb 25;214:112005.

纯度： ≥98%

Data Sheet

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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Other Forms of Rapamycin:

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