NSC5844 (RE-640) 是 4-氨基喹啉衍生物，具有抗肿瘤和抗疟疾 (antimalarial) 活性。
| 生物活性 |
NSC5844 (RE-640) is a 4-aminoquinoline derivative, with antitumor and antimalarial activity. |
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| 体外研究 |
NSC5844 (Compound 10) is a 4-aminoquinoline derivative, and has antitumor activity with GI50s of 7.35 ± 0.10 μM and 14.80 ± 0.35 μM against MDA-MB-468 and MCF-7 cells, respectively. NSC5844 (Compound 1) is cytotoxic to P. falciparum, inhibits the growth of chloroquine-sensitive (D-6) and -resistant (W-2) clones of P. falciparum, with IC50s of 17 and 27 nM, respectively. |
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| 分子式 |
C20H16Cl2N4
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| 分子量 |
383.27
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| CAS号 |
140926-75-6
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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纯度： ≥98%
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