ABMA - CAS:332108-65-3 - KKL Med Inc.

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ABMA

目录号 : KM3036 CAS No. : 332108-65-3 纯度 : 98%

Data Sheet 产品使用指南

ABMA 是一种细胞内毒素和病原体的广谱抑制剂。ABMA 有效地保护细胞免受各种毒素和病原体的侵害，包括病毒，细胞内细菌和寄生虫。ABMA 选择性作用于宿主细胞晚期内体，而不是针对毒素或病原体本身，具有广谱抗感染活性。

规格	价格	是否有货
10mg		In-stock
50mg		In-stock
100mg		In-stock
200mg	询价	In-stock
500mg	询价	In-stock

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生物活性

ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite. ABMA selectively acts at host cell late endosomes rather than targeting toxin or pathogen itself. ABMA has broad-spectrum anti-infection activity.

体外研究

ABMA protects cells against four bacterial toxins (Corynebacterium diphtheriae (DT; EC₅₀ of 62.9 μM), Bacillus anthracis (LT), Clostridium difficile toxin B (TcdB; EC₅₀ of 73.3 µM), Clostridium sordellii lethal toxin (TcsL; EC₅₀ of 86.7 μM)), three viruses (Ebola (EC₅₀ of 3.3 µM), rabies (EC₅₀ of 19.4 µM), dengue-4 virus ( EC₅₀ of 8.2 µM)), two species of Chlamydiales intracellular bacteria (Simkania negevensis and Chlamydia trachomatis), and the parasite Leishmania infantum (EC₅₀ of 7.1 µM) at micromolar level.
In A549 cells, ABMA treatment induces a decrease in ricin cytotoxicity with an EC₅₀ of 3.8 µM, and a protection factor (R) at 30 µM ranging from 5 to 10. ABMA retained almost 100% of its biological activity against ricin-induced cytotoxicity up to six days.

体内研究

ABMA (2-200 mg/kg; intraperitoneal injection; female BALB/c mice) treatment protects mice from nasal instillation of an LD₉₀ of ricin.

Animal Model:	Pathogen-free female BALB/c mice (6 week-old) with ricin
Dosage:	2 mg/kg, 20 mg/kg, 200 mg/kg
Administration:	Intraperitoneal injection
Result:	A statistically significant protection according to survival curves was observed with a single ip dose of 2 mg/kg. The 20 mg/kg dose fully protected animals through to day 21. The 200 mg/kg dose resulted in 80% of protection of mice against ricin challenge with a single animal succumbing on day 15.

分子量

350.29

CAS号

332108-65-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 125 mg/mL (356.85 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8548 mL	14.2739 mL	28.5478 mL
5 mM	0.5710 mL	2.8548 mL	5.7096 mL
10 mM	0.2855 mL	1.4274 mL	2.8548 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 6.25 mg/mL (17.84 mM); Clear solution

此方案可获得 ≥ 6.25 mg/mL (17.84 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 62.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 6.25 mg/mL (17.84 mM); Clear solution

此方案可获得 ≥ 6.25 mg/mL (17.84 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 62.5 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 6.25 mg/mL (17.84 mM); Clear solution

此方案可获得 ≥ 6.25 mg/mL (17.84 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 62.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。