Z-Ile-Leu-aldehyde - CAS:161710-10-7

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Z-Ile-Leu-aldehyde (Synonyms:Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII)

目录号 : KM3015 CAS No. : 161710-10-7 纯度 : ≥98%

Data Sheet 产品使用指南

Z-Ile-Leu-aldehyde (Z-IL-CHO) 是有效的、竞争性的 γ-secretase 和 notch 的肽醛抑制剂。

规格	价格	是否有货
2mg		In-stock
5mg		In-stock
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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生物活性

Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch.

体外研究

Z-Ile-Leu-aldehyde (ILCHO) significantly downregulates Th17-associated cytokine levels in murine Th17 in vitro polarization assays.
Z-Ile-Leu-aldehyde (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity.

RT-PCRsup>[1]

Cell Line:	CD4 T cells from C57BL/6 mice.
Concentration:	25 μM.
Incubation Time:	24, 48, 72 hours.
Result:	DownregulateD RORt and IL-17 mRNA expression.

Cell Viability Assaysup>[2]

Cell Line:	MOPC315.BM cells.
Concentration:	0, 12, 15 μM.
Incubation Time:	24-48 h hours.
Result:	Reduced viability and induced apoptosis in MOPC315.BM cells

体内研究

Z-Ile-Leu-aldehyde (GSI XII, 10 mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells and possibly in osteoclasts in their microenvironment.

Animal Model:	MOPC315.BM mouse model.
Dosage:	10 mg/kg.
Administration:	Intraperitoneally either for 14 days.
Result:	Reduces myeloma-specific paraprotein levels in the MOPC315.BM model. Diminished osteolytic lesions in the MOPC315.BM mice.

分子式

C₂₀H₃₀N₂O₄

分子量

362.46

CAS号

161710-10-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 41 mg/mL (113.12 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7589 mL	13.7946 mL	27.5893 mL
5 mM	0.5518 mL	2.7589 mL	5.5179 mL
10 mM	0.2759 mL	1.3795 mL	2.7589 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

科研文献

•Front Mol Biosci. 2021 Oct 22;8:652443.

纯度： ≥98%

Data Sheet

产品使用指南

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稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量*

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

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Other Forms of Rapamycin:

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