致电 400-881-9290
登录/ 注册
0 我的购物车
您当前的位置：
  1. 首页
  2. Signal path
  3. Membrane Transporter/Ion Channel | 跨膜转运
  4. Membrane Transporter/Ion Channel——nAChR
Zaldaride maleate (Synonyms:CGS-9343B; KW 5617)
目录号 : KM2627 CAS No. : 109826-27-9 纯度 : ≥98%
Data Sheet 产品使用指南

Zaldaride maleate (CGS-9343B) 是一个有效的、有口服活性的、选择性的钙调蛋白 (calmodulin) 的抑制剂，可抑制钙调蛋白刺激cAMP磷酸二酯酶的活性，IC50 值为 3.3 nM。Zaldaride maleate (CGS-9343B) 可抑制雌激素诱导的 ER 转录激活，可逆地阻断 PC12 细胞中电压激活的的 Na+、Ca2+和 K+电流，抑制 nAChR。

规格 价格 是否有货 数量
5mg
In-stock
10mg 询价 In-stock
50mg 询价 In-stock
加入购物车 大包装询价

Other Forms of Rapamycin:

KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。
生物活性

Zaldaride maleate (CGS-9343B) is a potent, orally active and selective inhibitor of calmodulin. Zaldaride maleate (CGS-9343B) inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC50 of 3.3 nM. Zaldaride maleate (CGS-9343B) prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na, Ca and K currents in PC12 cells and inhibits nAChR.

体内研究

Zaldaride maleate (KW 5617, P.O., 3 mg/kg) ameliorates the diarrhea in the 16, 16-dimethyl prostaglandin E2 model.

Animal Model: Male Sprague-dawley rats neighing 193-265 g.
Dosage: 3-100 mg/kg.
Administration: P.O..
Result: KW-5617 at 3 to100 mg/kg 60 min before DMPGE2 challenge, significantly ameliorated the DMPGE-induced diarrhea, when this drug at 100 mg/kg (p.o. significantly reduced fecaevacuation.
Pretreatment with KW-5617 at 3 to 10 mg/kg (p.o.) significantly delayed the onset of diarrhea, and this drug at 30 and 100 mg/kg (p.o. ) reduced or abolished the incidence of diarrhea.
分子式
C26H28N4O2.C4H4O4
分子量
544.60
CAS号
109826-27-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
重置 计算
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
重置 计算
联系我们
400-881-9290

technical-service@kklmed.com

terminal-order@kklmed.com

terminal-inspection@kklmed.com

dealer-order@kklmed.com

 10338 stony run ln，ste121，ashland，va，23005，USA
KKL MED 小分子
KKL MED

关注我们

获得KKL MED 最新资讯

Copyright © 2013-2022 KKL Med Inc. All Rights Reserved. 粤ICP备2022038512号-1
在线客服
咨询热线
400-881-9290
关注微信公众号
首页 分类 购物车 会员