Schisandrol B - CAS:58546-54-6

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Schisandrol B (Synonyms:五味子醇乙; Gomisin-A; TJN-101; Wuweizi alcohol-B)

目录号 : KM20332 CAS No. : 58546-54-6 纯度 : 98%

Data Sheet 产品使用指南

Schisandrol B (Gomisin-A) 是 Schisandra sphenanthera 的主要活性成分，具有保肝作用。Schisandrol B 抑制活性氧 (ROS) 的产生。Schisandrol B 抑制 P-糖蛋白和 CYP3A 的活性，还具有抗炎，抗糖尿病和抗氧化的作用。

规格	价格	是否有货
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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生物活性

Schisandrol B (Gomisin-A) is a major active constituent of Schisandra sphenanthera with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities.

体外研究

Schisandrol B (Gomisin-A; 1-10 μM; 2 days) treatment decreases the aging related inflammatory molecules, such as, COX-2, IL1β, and TNF-α. Schisandrol B attenuates the activity of senescence-associated β-galactosidase.
Schisandrol B (Gomisin-A; 1-10 μM; 2 days) inhibits reactive oxygen species production even in the stress-induced premature senescence (SIPS)-human diploid fibroblast (HDF) cells.
Schisandrol B (Gomisin-A; 1-10 μM) inhibits the MAPK pathway and the translocation of NF-κB to the nucleus.
Schisandrol B (Gomisin-A; 1-10 μM) promotes the autophagy and mitochondrial biogenesis factors through the translocation of Nrf-2, and inhibits aging progression in the SIPS-HDF cells.
Schisandrol B (0-80 μM) dramatically alters APAP metabolic activation by inhibiting the activities of CYP2E1 and CYP3A11.

Western Blot Analysis

Cell Line:	Human diploid fibroblast (HDF) cells
Concentration:	1 μM, 10 μM
Incubation Time:	3 days
Result:	Decreased the aging related inflammatory molecules, such as, COX-2, IL1β, and TNF-α.

体内研究

Schisandrol B (12.5 -200 mg/kg; oral administration; seven times with an interval of 12 hours) pretreatment significantly attenuates the increases in alanine aminotransferase and aspartate aminotransferase activity, and prevents elevated hepatic malondialdehyde formation and the depletion of GSH in a dose-dependent manner. Schisandrol B abrogates APAP-induced activation of p53 and p21, and increases expression of liver regeneration and antiapoptotic-related proteins such as cyclin D1 (CCND1), PCNA, and BCL-2.

Animal Model:	Male C57BL/6 mice (6-8 weeks old, 20-22 g) injected with Acetaminophen (APAP)
Dosage:	12.5 mg/kg, 12.5 mg/kg and 200 mg/kg
Administration:	Oral administration; seven times with an interval of 12 hours
Result:	Showed a protective effect against APAP-induced liver injury in mice.

分子式

C₂₃H₂₈O₇

分子量

416.46

CAS号

58546-54-6

中文名称

五味子醇乙

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 50 mg/mL (120.06 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4012 mL	12.0060 mL	24.0119 mL
5 mM	0.4802 mL	2.4012 mL	4.8024 mL
10 mM	0.2401 mL	1.2006 mL	2.4012 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (6.00 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: 2.5 mg/mL (6.00 mM); Suspended solution; Need ultrasonic

此方案可获得 2.5 mg/mL (6.00 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (6.00 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。