Polymyxin B1 - CAS:4135-11-9

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Polymyxin B1 (Synonyms:硫酸多粘菌素 B1；多粘菌素 B1 硫酸酯；托吡卡胺硫酸多粘菌素 B1；多粘菌素 B1 硫酸盐；硫酸多粘 B1)

目录号 : KM20213 CAS No. : 4135-11-9 纯度 : ≥96%

Data Sheet 产品使用指南

Polymyxin B1 是一种有效的抗菌脂肽，衍生自多头芽孢杆菌。Polymyxin B1 是 Polymyxin B 的主要成分。Polymyxin B1 可以通过与细菌细胞膜的相互作用来诱导细菌细胞裂解。Polymyxin B1 可用于多重耐药性革兰氏阴性菌感染的研究。

规格	价格	是否有货	数量
1mg		In-stock

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生物活性	Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B . Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment.
体外研究	Polymyxin B1 has antimicrobial activity that againsts Pseudomonas aeruginosa ATCC 27853, Acinetobacter baumannii ATCC BAA 747, Klebsiella pneumoniae ATCC 13883, P. aeruginosa 9019, A. baumannii 1261 and K. pneumoniae VM9 isolates with MIC values of 4 μg/mL, 2 μg/mL, 2 μg/mL, 4 μg/mL, 4 μg/mL and 2 μg/mL, respectively. Polymyxin B1 strongly inhibits protein synthesis in yeast, and in E. coli and S. aureus.
体内研究	The pharmacokinetics of Polymyxin B1 is investigated in a rat model following intravenous administration (0.8 mg/kg). The area under the concentration-time curve for Polymyxins B1 is greater than those of colistins A and B. Colistin A colistin B. The clearance value of Polymyxins B1 is 2.39 mL/min/kg, the plasma protein binding is 82.3%, the elimination half-life is 79.5 min and the AUC_0-∞ is 365 mg•min/L.
分子式	C₅₆H₉₈N₁₆O₁₃
分子量	1203.48
CAS号	4135-11-9
中文名称	硫酸多粘菌素 B1；多粘菌素 B1 硫酸酯；托吡卡胺硫酸多粘菌素 B1；多粘菌素 B1 硫酸盐；硫酸多粘 B1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)