Saikogenin D 分离自 Bupleurum chinense ，具有抗炎作用。Saikogenin D 激活环氧合酶，将花生四烯酸转化为环氧二十烷酸和二羟基二十碳三烯酸，其代谢产物继而抑制前列腺素E2 (PGE2) 的产生。 由于细胞内 Ca2+ 的释放，Saikogenin D 导致 [Ca2+]i 升高。
| 生物活性 |
Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca]i due to Ca release from intracellular stores. |
|---|---|
| 体外研究 |
Saikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca ionophore A23187 in a concentration-dependent manner with an IC50 value of 3 μM in C6 rat glioma cells. |
| 分子式 |
C30H48O4
|
| 分子量 |
472.70
|
| CAS号 |
5573-16-0
|
| 中文名称 |
皂苷元 D
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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