TP508 - CAS:121341-81-9

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TP508

目录号 : KM19588 CAS No. : 121341-81-9

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TP508 是一种 23 个氨基酸的非蛋白水解凝血酶肽，代表凝血酶分子受体结合结构域的一部分。TP508 可激活内皮 NO synthase (eNOS) 并刺激人内皮细胞中 NO 的产生。TP508 通过激活内皮细胞和干细胞以使血管再生和组织再生。

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1mg		In-stock
5mg		In-stock

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生物活性

TP508 is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 activates endothelial cells and stem cells to revascularize and regenerate tissues.

体外研究

TP508 (50 μg/mL; 24 hours; HCAEC) treatment reverses radiation-induced endothelial dysfunction (ED) and loss of NO signaling by attenuating the downregulation of eNOS expression. TP508 treatment is able to stimulate NO production in the irradiated cells.
TP508 mitigates effects of nuclear radiation on human endothelial cells in culture restoring endothelial NO production, tube formation and accelerating repair of radiation-induced DNA double-strand breaks (DSB).
TP508 acts as an antagonist for the effects of thrombin. TP508 peptide inhibits these thrombin-induced effects through a RGD and αvβ3-related mechanism.

Western Blot Analysis

Cell Line:	Primary human coronary artery endothelial cells (HCAEC)
Concentration:	50 μg/mL
Incubation Time:	24 hours
Result:	Prevented the radiation-induced downregulation of eNOS.

体内研究

TP508 (10 mg/kg; intravenous injection; male CD-1 mice) treatment mitigates radiation-induced endothelial cell damage, also significantly increases survival of CD-1 mice when injected 24 h after 8.5 Gy exposure.

Animal Model:	Male CD-1 mice (12-15-week old) with γ irradiation
Dosage:	10 mg/kg
Administration:	Intravenous injection
Result:	Mitigated radiation-induced endothelial cell damage, also significantly increased survival of CD-1 mice.

分子量

2312.44

CAS号

121341-81-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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