Dacarbazine - CAS:4342-03-4

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Dacarbazine (Synonyms:达卡巴嗪; Imidazole Carboxamide)

目录号 : KM19291 CAS No. : 4342-03-4 纯度 : ≥98%

Data Sheet 产品使用指南

Dacarbazine(DTIC-Dome; DTIC)有抗黑色素瘤活性。

规格	价格	是否有货
200mg		In-stock
1g		In-stock
5g	询价	In-stock
10g	询价	In-stock

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生物活性

Dacarbazine(DTIC-Dome; DTIC) is an antineoplastic agent. It has significant activity against melanomas. Target: Nucleoside antimetabolite/analog Approved: May 1975 Dacarbazine (DTIC) is the only single-agent approved by the Food and Drug Administration for treating metastatic melanoma. With DTIC as single agent, an approximately 20% objective response rate can be achieved with median response duration of 5 to 6 months and complete response rates of 5% [1]. Dacarbazine (DTIC) has activity in advanced previously untreated pancreatic islet cell tumors [2]. In the intent-to-treat population, median survival time was 7.7 months for patients treated with temozolomide and 6.4 months for those treated with DTIC (hazards ratio, 1.18; 95% confidence interval [CI], 0.92 to 1.52). Median PFS time was significantly longer in the temozolomide-treated group (1.9 months) than in the DTIC-treated group (1.5 months) (P = .012; hazards ratio, 1.37; 95% CI, 1.07 to 1.75) [3].

分子式

C₆H₁₀N₆O

分子量

182.18

CAS号

4342-03-4

中文名称

达卡巴嗪；达卡巴嗪柠檬酸盐；达卡比嗪；氨烯咪胺；氮烯唑胺；枸橼酸达卡巴嗪；枸橼酸氮烯咪胺；甲氮咪胺；甲嗪咪唑胺；卡达巴抗黑瘤；抗黑瘤素；三氯烯咪唑胺；三嗪咪唑；三嗪咪唑胺

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 6.42 mg/mL (35.24 mM; Need ultrasonic and warming)

H₂O : < 0.1 mg/mL (insoluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.4891 mL	27.4454 mL	54.8908 mL
5 mM	1.0978 mL	5.4891 mL	10.9782 mL
10 mM	0.5489 mL	2.7445 mL	5.4891 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 50% PEG300 50% saline
Solubility: 5 mg/mL (27.45 mM); Suspended solution; Need ultrasonic

临床试验

科研文献

纯度： ≥98%

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 3 篇科研文献

The molarity calculator equation

The dilution calculator equation