Silymarin - CAS:65666-07-1

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Silymarin (Synonyms:水飞蓟素)

目录号 : KM19224 CAS No. : 65666-07-1 纯度 : ≥80%

Data Sheet 产品使用指南

Silymarin 是水飞蓟 (Silybum marianum) 的提取物。Silymarin 是食品来源的抗病毒分子，是一种有效的 SARS-CoV-2 主蛋白酶 (M^pro) 抑制剂。Silymarin 可以显着降低肿瘤细胞的增殖，血管生成以及胰岛素抵抗。Silymarin 对于肝细胞癌 (HCC) 具有化学预防作用。Silymarin 具有用于 COVID-19 研究的潜力。

规格	价格	是否有货
250mg		In-stock
500mg		In-stock
1g	询价	In-stock
5g	询价	In-stock

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生物活性

Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin, a food-derived antiviral molecule, is an effective SARS-CoV-2 main protease (M) inhibitor. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC). Silymarin has the potential for COVID-19 research.

体外研究

Silymarin (0-120 µg/ml; 24 hours) inhibits AGS cell viability, the viability of AGS cells is 77.9% in the presence of 20 µg/ml silymarin, 71.5% at 40 µg/ml, 59.8% at 60 µg/ml, 44.5% at 80 µg/ml, 35.3% at 100 µg/ml and 33.9% at 120 µg/ml.
Silymarin (40-80 µg/ml; 24 hours) inhibits the migration of the AGS cells in a concentration-dependent manner. It inhibit migration of AGS cells 59.4% at 40 µg/ml and 21.7% at 80 µg/ml,respectively.

Cell Viability Assay

Cell Line:	AGS cells
Concentration:	20 µg/ml, 40 µg/ml, 80 µg/ml, 100 µg/ml and 120 µg/ml
Incubation Time:	24 hours
Result:	Indicated a significant concentration-dependent inhibitory effect on AGS cells starting at 20 µg/ml.

体内研究

Silymarin (oral gavage; 10, 20, 50, 100, and 200 mg/kg) decreases the immobility time in a dose-dependent manner in forced swimming test (FST). It also lowers the immobility measure dose-dependently in tail suspension test (TST). Additionally, 50% of maximum response (ED₅₀) of Silymarin is around 10 mg/kg. The dose 100 mg/kg proved the most effective dose in both the tests.

分子式

C₂₅H₂₂O₁₀

CAS号

65666-07-1

中文名称

水飞蓟素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 120 mg/mL (Need ultrasonic)

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 3 mg/mL (Infinity mM); Clear solution

此方案可获得 ≥ 3 mg/mL (Infinity mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 30.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。