Mirtazapine (intraperitoneal injection; 10–50 mg/Kg; 14 days) treatment normalizes heart rate, breath rate, anxiety levels and eliminates the hopping behavior observed in MeCP2-null mice, leading to improved phenotypic score.
Animal Model: |
MeCP2 null mice |
Dosage: |
10-50 mg/Kg |
Administration: |
Intraperitoneal injection; 10-50 mg/Kg; 14 days |
Result: |
Restored the thickness of MeCP2-null mice somatosensory cortex, especially of layers II-III and VI. |