N-Methylmoranoline - CAS:69567-10-8

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N-Methylmoranoline (Synonyms:MOR 14; N-Methyl-1-deoxynojirimycin; N-Methylmoranolin)

目录号 : KM18370 CAS No. : 69567-10-8

Data Sheet 产品使用指南

N-Methylmoranoline (MOR 14)是 α-glucosidase 的抑制剂。

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生物活性	N-Methylmoranoline (MOR 14) is an α-glucosidase inhibitor.
体外研究	N-Methylmoranoline dose-dependently decreases the α-1,6-glucosidase activity in rabbit heart extract. The myocardial uptake of a considerable amount of N-Methylmoranoline is sufficient to fully inhibit alpha-1,6-glucosidase. Preischemic treatment with 25, 50, and 100 mg/kg of N-Methylmoranoline dose-dependently reduces the infarct size without altering the blood pressure or heart rate. MOR-14 significantly increases levels of PKC-ε in the particulate fraction at 20 and 30 min of ischaemia and in the cytosolic fraction at 30 min of ischaemia.
体内研究	N-Methylmoranoline decreases the alpha-1,6-glucosidase activity to approximately 20%, reduces the glycogen breakdown, and attenuates the lactate accumulation at both 10 and 30 minutes of ischemia. MOR-14 is protective against postischemic left ventricular dysfunction through the inhibition of glycogenolysis in the isolated rat heart.
分子式	C₇H₁₅NO₄
分子量	177.20
CAS号	69567-10-8
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.