Ecdysone - CAS:3604-87-3

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Ecdysone (Synonyms:蜕皮激素; α-Ecdysone)

目录号 : KM18269 CAS No. : 3604-87-3

Data Sheet 产品使用指南

Ecdysone (α-Ecdysone) 是昆虫和草药中的主要类固醇激素，可以激活盐皮质激素受体 (MR) 并诱导细胞凋亡 (apoptosis)。Ecdysone 通过其活性代谢物 20-羟基蜕皮激素 (Crustecdysone; 20E; ) 在协调发育过渡和体内稳态睡眠调节中起重要作用。

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5mg		In-stock

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生物活性

Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E).

体外研究

Ecdysone (α-Ecdysone; 100 nM; for 48 hours) causes renal tubular inner medullary collecting duct cells (IMCD) apoptosis.
Ecdysone (10, 100 nM; for 48 hours) induces the expression of a-smooth muscle actin (SMA), a standard mesenchymal marker in a dose dependent fashion in inner medullary collecting duct cells (IMCD). Ecdysone elevates the expression of cleaved caspase 3 in a dose dependent fashion.
Ecdysone (10, 100 nM; for 12, 24 hours) suppresses cell motility and scratch wound closure to a comparable extent.
Ecdysone treatments (100 nM; for 24, 48 hours) induces a branched spindle mesenchymal-like cell shape.

Apoptosis Analysis

Cell Line:	Inner medullary collecting duct cells (IMCD)
Concentration:	100 nM
Incubation Time:	For 48 hours
Result:	Caused renal tubular cell apoptosis.

Western Blot Analysis

Cell Line:	IMCD cells
Concentration:	10, 100 nM
Incubation Time:	For 48 hours
Result:	Induced the expression of a-smooth muscle actin (SMA), a standard mesenchymal marker in a dose dependent fashion.

体内研究

Ecdysone (α-Ecdysone; 6 µg/g/day; SC; for 14 days) evidently impaires kidney function marked by a statistically significant increase in BUN levels and amplifies renal expression of α-SMA in male C57BL/6 mice aged 10 weeks. Ecdysone confers an MR dependent nephropathic effect.

分子式

C₂₇H₄₄O₆

分子量

464.63

CAS号

3604-87-3

中文名称

蜕皮激素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet

产品使用指南

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