L-Cystathionine - CAS:56-88-2

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L-Cystathionine (Synonyms:L-胱硫醚)

目录号 : KM18108 CAS No. : 56-88-2 纯度 : 98%

Data Sheet 产品使用指南

L-Cystathionine 是一种非蛋白质硫醚，是与含硫氨基酸代谢状态有关的关键氨基酸。L-Cystathionine 可防止高半胱氨酸诱导的线粒体依赖性血管内皮细胞 (HUVECs) 凋亡。L-Cystathionine 在心血管保护中起重要作用。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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生物活性

L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection.

体外研究

Homocysteine obviously induces the apoptosis of HUVECs, and this effect is significantly attenuated by the pretreatment with L-cystathionine. Furthermore, L-cystathionine decreases the production of mitochondrial superoxide anion and the expression of Bax and restrained its translocation to mitochondria, increases mitochondrial membrane potential, inhibits mitochondrial permeability transition pore (MPTP) opening, suppresses the leakage of cytochrome c from mitochondria into the cytoplasm, and downregulated activities of caspase-9 and caspase-3.
L-Cystathionine is an important metabolic intermediate in the L-cysteine transsulfuration pathway from L-methionine via L-homocysteine in mammalian tissues.

分子式

C₇H₁₄N₂O₄S

分子量

222.26

CAS号

56-88-2

中文名称

L-胱硫醚

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据

In Vitro:

H₂O : 25 mg/mL (112.48 mM; ultrasonic and warming and adjust pH to 11 with NaOH and heat to 80°C)

DMSO : 1 mg/mL (4.50 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.4992 mL	22.4962 mL	44.9924 mL
5 mM	0.8998 mL	4.4992 mL	8.9985 mL
10 mM	0.4499 mL	2.2496 mL	4.4992 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%