Calcimycin (A-23187) hemimagnesium 是一种抗生素和独特的二价阳离子离子载体 (divalent cation ionophore)，如钙离子和镁离子。Calcimycin hemimagnesium 通过增加细胞内钙浓度诱导 Ca2+ 依赖性细胞死亡。Calcimycin hemimagnesium 抑制革兰氏阳性细菌和一些真菌的生长，还抑制 ATP 酶的活性并解耦哺乳动物细胞的氧化磷酸化 (OXPHOS)，诱导细胞凋亡 (apoptosis)。
| 生物活性 |
Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis. |
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| 体外研究 |
Calcimycin (A-23187) hemimagnesium mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner. |
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| 体内研究 |
Calcimycin (A-23187) hemimagnesium (2.5 or 7.5 nM; intrapleurally) induces protein leakage.
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| 分子式 |
C58H72MgN6O12
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| 分子量 |
1069.53
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| CAS号 |
72124-77-7
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 临床试验 |
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| 科研文献 |
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