Compstatin (Synonyms:坎普他汀)
目录号 : KM17516 CAS No. : 206645-99-0

Compstatin 是一个 13 残基环肽,是补体系统 C3 的有效抑制剂,具有物种特异性。Compstatin 结合到狒狒的 C3,并对狒狒血液中的蛋白水解裂解具有抗性 (类似人类)。Compstatin 只抑制灵长类补体系统的激活。Compstatin 对补体经典途径和旁路途径的 IC50 值分别为 63 μM 和 12 μM。

规格 价格 是否有货 数量
500μg
In-stock
1mg
In-stock
5mg
In-stock

Other Forms of Rapamycin:

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生物活性

Compstatin, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin inhibits only the activation of primates’ complement system. Compstatin exhibits IC50 values of 63 μM and 12 μM for classical and alterative complement pathway, respectively.

体外研究

Compstatin exhibits an in vitro half-life in human blood of about2 hr.
In solution, compstatin forms a β-turn at residues Gln-5–Gly-8 with the disulfide bridge Cys-2–Cys12, residues Ile-1–Val-4, and Thr-13, forming a hydrophobic cluster.

体内研究

Compstatin (21 mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arterial, central venous, and pulmonary arterial pressures.
Compstatin is stable in baboon plasma for more than 24 h.
Pig xenografts survival is significantly longer in the Compstatin perfused group than in the control group.

Animal Model: Juvenile baboons (P. Anubis) weighing 10.5-28.8 kg.
Dosage: 50, 25 mg/kg 60 min after heparin and 2 min before protamine.
Administration: A bolus injection.
Result: Completely inhibited complement activation induced by heparin–protamine complexes.
分子式
C66H99N23O17S2
分子量
1550.77
CAS号
206645-99-0
中文名称
坎普他汀
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
科研文献
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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