Polygalacin D - CAS:66663-91-0

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Polygalacin D

目录号 : KM17387 CAS No. : 66663-91-0 纯度 : 98%

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Polygalacin D (PGD) 是从桔梗 Platycodon grandiflorum 中分离的具有抗癌和抗增殖特性的生物活性化合物。 Polygalacin D 抑制 IAP 蛋白家族的表达，包括存活蛋白，cIAP-1 和 cIAP-2 蛋白，并通过抑制 GSK3β，Akt 的磷酸化和PI3K 的表达来阻断 PI3K/Akt 途径。Polygalacin D 通过 PI3K/Akt 途径诱导凋亡 (apoptosis)。

规格	价格	是否有货
1mg		In-stock
5mg		In-stock
10mg	询价	In-stock
50mg	询价	In-stock

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生物活性

Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum (Jacq.) with anticancer and anti-proliferative properties. PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis

体外研究

Polygalacin D (0-40 µM; 48 hours) inhibits cell proliferation with IC₅₀s of 26.49 µM in the A549 cells and 20.52 µM in the H460 cells.
Polygalacin D (0-20 µM; 48 hours) increases the proportion of early and late apoptotic cells, and nuclear condensation is observed in A549 and H460 cells.
Polygalacin D (0-20 µM; 48 hours) may exerts its apoptotic effects by regulating the apoptotic proteins and the IAP family of proteins in A549 and H460 cells.

Cell Proliferation Assay

Cell Line:	A549 and H460 cancer cell lines
Concentration:	10 µM, 20 µM, 40µM
Incubation Time:	48 hours
Result:	Inhibited the proliferation of NSCLC cell lines.

Apoptosis Analysis

Cell Line:	A549 and H460 cancer cell lines
Concentration:	10 µM, 20 µM
Incubation Time:	48 hours
Result:	Induced apoptosis of NSCLC cell lines.

Western Blot Analysis

Cell Line:	A549 and H460 cancer cell lines
Concentration:	10 µM, 20 µM
Incubation Time:	48 hours
Result:	Decreased survivin, c-IAP-1 and c-IAP-2 expression.

分子式

C₅₇H₉₂O₂₇

分子量

1209.32

CAS号

66663-91-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

科研文献

•Free Radic Biol Med. 2020 Dec 8;S0891-5849(20)31642-7.

纯度： 98%

Data Sheet

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