PTH (80 μg/kg per day (hPTH), s.c., 4 weeks ) induces a ~35% recovery of this loss and a ~40% reversal of the associated decreases in trabecular number (Tb.N) and connectivity. PTH also causes a shift from single to double calcein-labeled trabecular surfaces, a significant enhancement in the mineralizing perimeter and a respective 2- and 3-fold stimulation of the mineral appositional rate (MAR) and bone formation rate (BFR).
Animal Model: |
Sixty-three 11-week-old virgin female Swiss-Webster mice. |
Dosage: |
80 μg/kg per day (hPTH). |
Administration: |
S.C., 4 weeks (5 days a week). |
Result: |
OVX osteoporotic mice respond to PTH by increased osteoblast activity and the consequent restoration of trabecular network. |