Doxycycline (hyclate) - CAS:24390-14-5

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Doxycycline (hyclate) (Synonyms:Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031)

目录号 : KM15555 CAS No. : 24390-14-5 纯度 : 97%

Data Sheet 产品使用指南

Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate) 是一种四环素抗生素，口服有效的，广谱的金属蛋白酶 (MMP) 抑制剂，具有抗菌活性。

规格	价格	是否有货	数量
100mg		In-stock
1g		In-stock
5g		In-stock
50g		In-stock
100g		In-stock

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生物活性

Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor.

体外研究

Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate) affects growth of glioma cells only under high concentrations.
Doxycycline (hyclate) decreases MT-CO1 protein content with concentrations of 1 µg/mL and higher in SVG cells.
Doxycycline (1 µg/mL) induce short-hairpin RNA (shRNA) expression in H23 cells.

Cell Proliferation Assay

Cell Line:	LNT-229, G55, and U343 glioma cells
Concentration:	0.01, 0.1, 1, or 10 µg/mL
Incubation Time:	4 days
Result:	Affected growth of glioma cells only under high concentrations.

Western Blot Analysis

Cell Line:	SVG cells
Concentration:	0.01, 0.1, 1, or 10 µg/mL
Incubation Time:	24 hours
Result:	Decreaseed MT-CO1 protein content with concentrations of 1 µg/mL and higher.

体内研究

Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate) (oral; 200 or 800 mg/kg/day; for 3 months) reduces active MMP-9 in untreated HT mice in a dose-dependent manner.

Animal Model:	6-month-old female Heterozygous Col3a1-deficient (HT) mice
Dosage:	200 or 800 mg/kg
Administration:	Oral; per day; for 3 months
Result:	Reduced active MMP-9 in a dose-dependent manner.

分子式

C₂₂H₂₄N₂O₈

分子量

512.94

CAS号

24390-14-5

中文名称

多西环素盐酸盐半乙醇半水合物；强力霉素盐酸盐半乙醇半水合物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 240 mg/mL (467.89 mM; Need ultrasonic)

H₂O : 125 mg/mL (243.69 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9495 mL	9.7477 mL	19.4955 mL
5 mM	0.3899 mL	1.9495 mL	3.8991 mL
10 mM	0.1950 mL	0.9748 mL	1.9495 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 20 mg/mL (38.99 mM); Clear solution; Need ultrasonic
2.

请依序添加每种溶剂： 5% DMSO 40% PEG300 5% Tween-80 50% saline
Solubility: ≥ 3 mg/mL (5.85 mM); Clear solution
3.

请依序添加每种溶剂： 5% DMSO 95% (20% SBE-β-CD in saline)
Solubility: ≥ 3 mg/mL (5.85 mM); Clear solution

临床试验

科研文献

纯度： 97%

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 24 篇科研文献

The molarity calculator equation

The dilution calculator equation