Tyloxapol - CAS:25301-02-4

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Tyloxapol (Synonyms:四丁酚醛; Triton WR1339)

目录号 : KM15503 CAS No. : 25301-02-4

Data Sheet 产品使用指南

Tyloxapol (Triton WR1339) 是一种烷基芳基聚醚醇型非离子液体聚合物，用作表面活性稳定剂。Tyloxapol (Triton WR1339) 用于诱导动物高脂血症。

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1g		In-stock
5g	询价	In-stock
10g	询价	In-stock

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生物活性

Tyloxapol (Triton WR1339) is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surface active stabilizer. Tyloxapol (Triton WR1339) is used to induce hyperlipidemia in animals.

体外研究

Tyloxapol (100 μg/mL) triggers the detachment of HEK293 cells.
Tyloxapol induces nuclear fragmentation and the appearance of apoptotic nuclei.
Tyloxapol increases the risk of pulmonary haemorrhage, causes cytotoxicity in epithelial and red blood cells, and induces lysis of human Jurkat T-lymphoblasts.

体内研究

Tyloxapol (Triton WR1339, 50 mg/kg) causes significant (P < 0.05) decreases in the activities of the AChE and MAO enzymes in rat plasma and brain.
Tyloxapol leads to significant (P < 0.05) reduction in the plasma urea, creatinine, and bilirubin.

Animal Model:	Twenty-one adult male Wistar rats, aged 11–12 weeks weighing 180-200 g.
Dosage:	50 mg/kg.
Administration:	Injected intraperitoneally, BW, every other day.
Result:	Caused a significant (P < 0.05) elevation in the levels of TBARS combined with an inhibition of the antioxidant enzymes (GPx, GST, CAT, SOD) in rat plasma, liver, and brain. Induced DNA fragmentation and inhibited the activities of acetylcholinesterase and mono aminoxidase in the brain.

分子式

C₁₇H₂₈O₃

分子量

280.41

CAS号

25301-02-4

中文名称

四丁酚醛；泰洛沙泊

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

H₂O : 120 mg/mL (Need ultrasonic)

Ethanol : 100 mg/mL (Need ultrasonic)

DMSO : ≥ 38 mg/mL

* "≥" means soluble, but saturation unknown.

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (Infinity mM); Clear solution; Need ultrasonic

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

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Other Forms of Rapamycin:

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The molarity calculator equation

The dilution calculator equation