Pentoxifylline - CAS:6493-05-6

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Pentoxifylline (Synonyms:己酮可可碱; BL-191; PTX; Oxpentifylline)

目录号 : KM15225 CAS No. : 6493-05-6 纯度 : 98%

Data Sheet 产品使用指南

Pentoxifylline (BL-191) 是一种血液流变学改善剂。Pentoxifylline 是一种具有口服活性的，非选择性的磷酸二酯酶 (PDE) 抑制剂，具有免疫调节、抗炎、血液流变学改善、抗纤溶和抗增殖作用。Pentoxifylline 可用于研究周围血管疾病、脑血管疾病和其他一些涉及局部微循环缺陷的疾病。

规格	价格	是否有货
500mg		In-stock
1g		In-stock
5g	询价	In-stock
10g	询价	In-stock

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Other Forms of Rapamycin:

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生物活性

Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation.

体外研究

Pentoxifylline (0.1-50 mM; 24-48 hours) inhibits cell proliferation in a dose-dependent manner.
Pentoxifylline (0.5 mM; 12-36 hours) increases apoptosis and decreases autophagy levels in MDA-MB-231 cells.
Pentoxifylline (0.5 mM; 12-36 hours) induces autophagy in MDA-MB-231 cells.
Pentoxifylline (0.5 mM; 24-48 hours) blocks cell cycle at the G0/G1 phase.
Pentoxifylline results in high LC3-II/LC3-ratio.

Cell Proliferation Assay

Cell Line:	MDA-MB-231 cells
Concentration:	0.1 mM, 1 mM, 5 mM , 10 mM, 50 mM
Incubation Time:	24 hours, 48 hours
Result:	Inhibited cell proliferation in a dose-dependent manner.

Apoptosis Analysis

Cell Line:	MDA-MB-231 cells
Concentration:	0.5 mM
Incubation Time:	12 hours, 24 hours, 36 hours
Result:	Induced apoptosis.

Cell Autophagy Assay

Cell Line:	MDA-MB-231 cells
Concentration:	0.5 mM
Incubation Time:	24 hours, 48 hours
Result:	Induced approximately 20-28% of cell autophagy.

Cell Cycle Analysis

Cell Line:	MDA-MB-231 cells
Concentration:	0.5 mM
Incubation Time:	24 hours, 48 hours
Result:	Induced G0/G1 phase arrest.

Western Blot Analysis

Cell Line:	MDA-MB-231 cells
Concentration:	0.5 mM
Incubation Time:	24 hours, 48 hours
Result:	Induced high LC3-II/LC3-ratio.

体内研究

Pentoxifylline (200 mg/kg; i.p.) has a protective effect on rats with transient global ischemia and reduces cognitive impairment.

Animal Model:	Adult male Wistar rats 12-13-weeks-old (250-300 g)
Dosage:	200 mg/kg
Administration:	Intraperitoneal injection, at 1hr before and 3 hr after ischemia
Result:	Significantly improved the spatial memory and effects were significant different from those of sham-operated and vehicle groups.

分子式

C₁₃H₁₈N₄O₃

分子量

278.31

CAS号

6493-05-6

中文名称

己酮可可碱；已酮可可碱

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 93.3 mg/mL (335.24 mM; Need ultrasonic and warming)

DMSO : ≥ 2.8 mg/mL (10.06 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.5931 mL	17.9656 mL	35.9312 mL
5 mM	0.7186 mL	3.5931 mL	7.1862 mL
10 mM	0.3593 mL	1.7966 mL	3.5931 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 110 mg/mL (395.24 mM); Clear solution; Need ultrasonic

临床试验

科研文献

纯度： 98%

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 2 篇科研文献

The molarity calculator equation

The dilution calculator equation