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Hexa-D-arginine (Synonyms:Furin Inhibitor II)
目录号 : KM14110 CAS No. : 673202-67-0 纯度 : 98%

Hexa-D-arginine (Furin Inhibitor II) 是一种稳定的 furin 抑制剂,对 furin,PACE4 和 PC1 的 Ki 值分别为 106 nM,580 nM 和 13.2 μM。Hexa-D-arginine 在体外和体内均可阻断假单胞菌外毒素 A 和炭疽毒素的毒性。

规格 价格 是否有货 数量
1mg
In-stock
5mg
In-stock
10mg
In-stock
50mg 询价 In-stock
100mg 询价 In-stock

Other Forms of Rapamycin:

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生物活性

Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo.

体外研究

Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic.

体内研究

Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α.

分子式
C36H75N25O6
分子量
954.14
CAS号
673202-67-0
中文名称
六-D-精氨酸
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : 50 mg/mL (52.40 mM; Need ultrasonic)

DMSO : 5 mg/mL (5.24 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0481 mL 5.2403 mL 10.4806 mL
5 mM 0.2096 mL 1.0481 mL 2.0961 mL
10 mM 0.1048 mL 0.5240 mL 1.0481 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

科研文献
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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