KKL 顾客使用本产品发表的 1 篇科研文献

Conophylline is a vinca alkaloid extracted from leaves of a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells. Conophylline suppresses HSC and induces apoptosis.

Conophylline (100 ng/ml; 48 hours) reproduces differentiationinducing activity but not apoptosis-inducing activity of activin.
Conophylline (100 ng/ml; 72 hours) exhibits the differentiation-inducing activity in AR42J cells and converts these cells to endocrine cells.
Conophylline increases the expression of neurogenin-3 by activating p38 mitogen-activated protein kinase to induce differentiation of AR42J cells.
Conophylline reduces the expression of α-SMA and collagen-1 in rat HSC and Lx-2 cells.
Conophylline inhibits DNA synthesis induced by serum.
Conophylline also promots activation of caspase-3 and induces apoptosis in Lx-2 Cells.

Conophylline (0.9 mg/kg; p.o.; daily; for 12 weeks) attenuates formation of the liver fibrosis induced by TAA in vivo.

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