Natamycin (Synonyms:纳他霉素; Pimaricin)
目录号 : KM13444 CAS No. : 7681-93-8 纯度 : 98%

Natamycin (Pimaricin) 是由数个链霉菌菌株生产的大环内酯类抗生素,可通过抑制氨基酸和葡萄糖跨质膜的运输来抑制真菌的生长。Natamycin (Pimaricin) 是一种食品防腐剂,在农业中是一种抗真菌剂,被广泛用于真菌性角膜炎的研究。

规格 价格 是否有货 数量
50mg
In-stock
100mg
In-stock
200mg
In-stock
500mg
In-stock
1g 询价 In-stock
5g 询价 In-stock

Other Forms of Rapamycin:

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生物活性

Natamycin (Pimaricin) is a macrolide antibiotic agent produced by several Streptomyces strains. Natamycin inhibits the growth of fungi via inhibition of amino acid and glucose transport across the plasma membrane. Natamycin is a food preservative, an antifungal agent in agriculture, and is widely used for fungal keratitis research.

体外研究

Natamycin, an important macrolide antibiotic, produced by several Streptomyces species, including S. natalensis, S. gilvosporeus, S. lydicus and S. chattanoogensis, can inhibit the growth of fungi via immediate inhibition of amino acid and glucose transport across the plasma membrane. Natamycin is widely used in the food industry and in pharmacotherapy for topical treatment. Unlike other polyene antibiotics, the mode of action of Natamycin is not based on the ergosterol-dependent permeabilization of the plasma membrane. The immediate cessation of growth of yeasts by Natamycin treatment indicates that there might be an instantaneous effect of Natamycin at the level of the plasma membrane.

分子式
C33H47NO13
分子量
665.73
CAS号
7681-93-8
中文名称
纳他霉素;游霉素;匹马菌素;那他霉素
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 16.67 mg/mL (25.04 mM; ultrasonic and adjust pH to 6 with HCl)

H2O : 1 mg/mL (1.50 mM; ultrasonic and warming and heat to 80°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5021 mL 7.5106 mL 15.0211 mL
5 mM 0.3004 mL 1.5021 mL 3.0042 mL
10 mM 0.1502 mL 0.7511 mL 1.5021 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (2.51 mM); Clear solution

    此方案可获得 ≥ 1.67 mg/mL (2.51 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 16.7 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.67 mg/mL (2.51 mM); Clear solution

    此方案可获得 ≥ 1.67 mg/mL (2.51 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 16.7 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

临床试验
科研文献
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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