Dicloxacillin Sodium hydrate (Synonyms:双氯西林钠; Dicloxacillin sodium salt monohydrate)
目录号 : KM13276 CAS No. : 13412-64-1 纯度 : ≥98%

Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) 是青霉素类的窄谱β内酰胺抗生素, 可用于革兰氏阳性菌感染的研究, 有效对抗β-内酰胺酶产生的微生物如金黄色葡萄球菌。

规格 价格 是否有货 数量
50mg
In-stock
100mg 询价 In-stock
200mg 询价 In-stock

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生物活性

Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) is a narrow-spectrum β-Lactam antibiotic of the penicillin class, is used to treat infections caused by susceptible Gram-positive bacteria, active against beta-lactamase-producing organisms such as Staphylococcus aureus.

体外研究

Dicloxacillin exhibits EC50 values of 0.06 and 0.50 mg/L in ATCC 25923 and E19977, respectively. Dicloxacillin exhibits MIC values of 0.125 and 0.5 mg/L in ATCC 25923 and E19977 with pH 7.4, respectively.

Cell Viability Assay

Cell Line: Strains ATCC 25923 and E19977.
Concentration: 0-500 mg/L.
Incubation Time: Up to 24 h.
Result: Exhibited EC50 values of 0.06 and 0.50 mg/L in ATCC 25923 and E19977, respectively.
体内研究

Dicloxacillin exhibits therapeutic activity in murine peritonitis-sepsis model and all the mice are survivied.

Animal Model: Female outbred Swiss Webster mice (Murine peritonitis-sepsis model).
Dosage: 125 mg/kg.
Administration: IV injection, single doses.
Result: All the mice survived.
分子式
C19H17N3O5Scl2.Na+
分子量
510.32
CAS号
13412-64-1
中文名称
双氯西林钠;双氯青霉素钠盐
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : 25 mg/mL (48.99 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9596 mL 9.7978 mL 19.5955 mL
5 mM 0.3919 mL 1.9596 mL 3.9191 mL
10 mM 0.1960 mL 0.9798 mL 1.9596 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

临床试验
科研文献
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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