Fenoterol hydrobromide (Synonyms:非诺特罗氢溴酸盐; Th-1165a; Phenoterol hydrobromide)
目录号 : KM13008 CAS No. : 1944-12-3 纯度 : 98%

Fenoterol hydrobromide (Th-1165a) 是拟交感神经剂,是一种选择性的,具有口服活性 β2-肾上腺素受体 (β2-adrenoceptor) 激动剂。Fenoterol hydrobromide 是一种有效的支气管扩张剂,可用于与哮喘,支气管炎和其他阻塞性气道疾病相关的支气管痉挛的研究。

规格 价格 是否有货 数量
100mg
In-stock
200mg 询价 In-stock
500mg 询价 In-stock

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生物活性

Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research.

体外研究

Fenoterol (1 μM; pre-incubated 30 minutes) treatment reduces AICAR-induced AMPK activation, NF-κB activation and TNF-α release, and also significantly downregulates the elevated phosphorylation levels of AMPK.
Fenoterol inhibits lipopolysaccharide (LPS)-induced AMPK activation and inflammatory cytokine production in THP-1 cells.
Fenoterol is also a potent exosome biogenesis and/or secretion activator in PC cells.

Western Blot Analysis

Cell Line: THP-1 cells stimulated with AICAR
Concentration: 1 μM
Incubation Time: Pre-incubated 30 minutes
Result: Significantly downregulated the elevated phosphorylation levels of AMPK.
体内研究

Fenoterol (0.7 mg/kg; intraperitoneal injection; twice a day; for 3 weeks) treatment suppresses mechanical allodynia during chronic treatment.

Animal Model: Male C57BL/6J mice (6 weeks old) with neuropathy
Dosage: 0.7 mg/kg
Administration: Intraperitoneal injection; twice a day; for 3 weeks
Result: Alleviated neuropathic allodynia during chronic treatment.
分子式
C17H21NO4.HBr
分子量
384.26
CAS号
1944-12-3
中文名称
非诺特罗氢溴酸盐
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 100 mg/mL (260.24 mM)

H2O : 25 mg/mL (65.06 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6024 mL 13.0120 mL 26.0240 mL
5 mM 0.5205 mL 2.6024 mL 5.2048 mL
10 mM 0.2602 mL 1.3012 mL 2.6024 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 60 mg/mL (156.14 mM); Clear solution; Need ultrasonic

  • 2.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.51 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.51 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

  • 3.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.51 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.51 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

  • 4.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.51 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.51 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

临床试验
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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