Pralidoxime iodide
目录号 : KM12931 CAS No. : 94-63-3 纯度 : ≥98%

Pralidoxime iodide 是乙酰胆碱酯酶 (AChE) 的活化剂。Pralidoxime iodide 能激活神经毒剂,抑制乙酰胆碱酯酶的活性,其途径是通过结合神经毒剂磷中心的肟部分直接亲核攻击。Pralidoxime iodide 是有机磷中毒的解毒剂。

规格 价格 是否有货 数量
25mg
In-stock
100mg
In-stock
250mg
In-stock
500mg 询价 In-stock
1g 询价 In-stock
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生物活性

Pralidoxime iodide is a reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent, which inhibits AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning.

体内研究

Pralidoxime iodide (10-150 mg/kg; i.m.) reverses paraoxon-induced respiratory toxicity in mice.

Animal Model: Male F1B6D2 mice (toxic but non-lethal model of diethylparaoxon in awake, unrestrained mice)
Dosage: 10, 50, 100 and 150 mg/kg
Administration: Intramuscularly
Result: Reversal of diethylparaoxon-induced respiratory toxicity at 150 mg/kg.
分子式
C7H9In2O
分子量
264.06
CAS号
94-63-3
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 250 mg/mL (946.75 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.7870 mL 18.9351 mL 37.8702 mL
5 mM 0.7574 mL 3.7870 mL 7.5740 mL
10 mM 0.3787 mL 1.8935 mL 3.7870 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

临床试验
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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