Roxatidine Acetate Hydrochloride 是一种选择性组胺 H2 受体 (histamine H2 receptor) 拮抗剂，可用于胃溃疡和十二指肠溃疡的研究。Roxatidine Acetate Hydrochloride 通过酯酶在小肠，血浆和肝脏迅速转化为其活性代谢物罗沙替丁。
| 生物活性 |
Roxatidine Acetate Hydrochloride (HOE 760) is a selective histamine H2 receptor antagonist, can be used for the research of gastric and duodenal ulcers. Roxatidine Acetate Hydrochloride can be rapidly converted to its active metabolite, roxatidine, by esterases in the small intestine, plasma, and liver. |
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| 体外研究 |
Roxatidine Acetate Hydrochloride (6.25 μM, 12.5 μM, and 25 μM; pre-treatment for 30 min) suppresses the PMACI-induced activation of p38 MAPK, but does not affect the phosphorylation of ERK or JNK. The total ERK 1/2, JNK, and p38 MAPK levels are unaffected by roxatidine in human mast-cells-1 (HMC-1) cells. |
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| 体内研究 |
Roxatidine Acetate Hydrochloride (oral gavage; 20 mg/kg; single dose) inhibits Compound 48/80-increased TNF-α, IL-6, and IL-1β production and mRNA expression. Additionally, Roxatidine decreases the compound 48/80-induced degradation of procaspase-1 and appearance of the corresponding cleaved bands in mice.
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| 分子式 |
C19H29ClN2O4
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| 分子量 |
384.90
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| CAS号 |
93793-83-0
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| 中文名称 |
盐酸罗沙替丁醋酸酯；盐酸醋酸罗沙替丁
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 溶解性数据 |
In Vitro:
DMSO : 50 mg/mL (129.90 mM; Need ultrasonic) H2O : ≥ 50 mg/mL (129.90 mM) * "≥" means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百
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纯度： 98%
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Data Sheet
