Validamycin A - CAS:37248-47-8

您当前的位置：

Validamycin A (Synonyms:井冈霉素A)

目录号 : KM12909 CAS No. : 37248-47-8 纯度 : ≥60%

Data Sheet 产品使用指南

Validamycin A 是一种杀菌剂，属于农用抗生素，最初从 Streptomyces hygroscopicus var. limoneus 中分离得到。Validamycin A 能抑制黄曲霉的生长, 其 MIC 值为 1 μg/mL。Validamycin A 对立枯丝核菌的海藻酸酶 (trehalase) 有高效的抑制活性，其 IC₅₀ 为 72 μM。Validamycin A 是一种可逆的酪氨酸酶抑制剂，其 K_i 值为 5.893 mM。

规格	价格	是否有货
100mg		In-stock
200mg	询价	In-stock
500mg	询价	In-stock

加入购物车大包装询价

Other Forms of Rapamycin:

Ginkgolic Acid (C13:0) In-stock
Lalistat 1 In-stock
Ciprofloxacin hydrochloride monohydrate In-stock
Cyclosporin C In-stock
Isobavachromene In-stock

KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。

生物活性

Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL. Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC₅₀ of 72 μM. Validamycin A is a reversible tyrosinase inhibitor, with a K_i of 5.893 mM.

体外研究

Validamycin A (0.5-1 μg/mL; 18 hours) inhibits the growth of A. flavus and delayed conidial germination.
Validamycin A shows no cytotoxicity to human bronchial epithelial cells.
Validamycin A directly binds to several residues in the active site of tyrosinase, including HIS85, HIS244, GLU256, HIS259 and ASN260.

Cell Proliferation Assay

Cell Line:	Aspergillus flavus ATCC204304
Concentration:	0.5 μg/mL, 1 μg/mL
Incubation Time:	18 hours
Result:	Inhibited the growth of Aspergillus flavus.

分子式

C₂₀H₃₅NO₁₃

分子量

497.49

CAS号

37248-47-8

中文名称

井冈霉素A

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据

In Vitro:

H₂O : 125 mg/mL (251.26 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0101 mL	10.0505 mL	20.1009 mL
5 mM	0.4020 mL	2.0101 mL	4.0202 mL
10 mM	0.2010 mL	1.0050 mL	2.0101 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥60%