Levofloxacin (Synonyms:左氧氟沙星; (--Ofloxacin))
目录号 : KM12857 CAS No. : 100986-85-4 纯度 : 98%

Levofloxacin是合成的氟喹诺酮类抗生素,能抑制细菌DNA旋转酶的超螺旋活性,可阻止DNA复制。

规格 价格 是否有货 数量
100mg
In-stock
5g
In-stock
10g 询价 In-stock
50g 询价 In-stock

Other Forms of Rapamycin:

KKL Med 的所有产品和服务仅用于科学研究,不能被用于人体,兽医,我们也不向个人提供产品和服务。
生物活性

Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. Target: Antibacterial Levofloxacin reduced bacterial load compared with placebo by 4.9-fold (95% confidence interval, 1.4-25.7; P=0.02) at day 7 but had no effect at any point on any marker of neutrophilic airway inflammation. In patients with a baseline bacterial load of more than 10(6) cfu/mL, levofloxacin treatment was associated with a 26.5% (95% confidence interval, 1.8%-51.3%; P=0.04) greater reduction in the percentage neutrophil count compared with placebo at day 7 . Levofloxacin was found to significantly improve the clinical and microbiological parameters in CP individuals . A 30-day course of levofloxacin does not significantly improve BK viral load reduction or allograft function when used in addition to overall reduction of immunosuppression .

分子式
C18H20FN3O4
分子量
361.37
CAS号
100986-85-4
中文名称
左氧氟沙星;左氟沙星;左旋氧氟沙星
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

H2O : ≥ 5 mg/mL (13.84 mM)

DMSO : 10 mg/mL (27.67 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7672 mL 13.8362 mL 27.6725 mL
5 mM 0.5534 mL 2.7672 mL 5.5345 mL
10 mM 0.2767 mL 1.3836 mL 2.7672 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 10 mg/mL (27.67 mM); Clear solution; Need ultrasonic

     

  • 2.

    请依序添加每种溶剂: 10% DMSO → 40% PEG300 → 5% Tween-80 →45% saline

    Solubility: ≥ 1 mg/mL (2.77 mM); Clear solution

    此⽅案可获得 ≥ 1 mg/mL (2.77 mM,饱和度未知) 的澄清溶液。

    以 1 mL ⼯作液为例,取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加⼊ 50 μ L Tween-80,混合均匀;然后继续加⼊ 450 μL ⽣理盐⽔定容⾄ 1 mL。

     
  • 3.

    请依序添加每种溶剂: 10% DMSO → 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1 mg/mL (2.77 mM); Clear solution

    此⽅案可获得 ≥ 1 mg/mL (2.77 mM,饱和度未知) 的澄清溶液。

    以 1 mL ⼯作液为例,取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD ⽣理盐⽔⽔溶液中,混合均 匀。

 
  • 4.

    请依序添加每种溶剂: 10% DMSO → 90% corn oil

    Solubility: ≥ 1 mg/mL (2.77 mM); Clear solution

    此⽅案可获得 ≥ 1 mg/mL (2.77 mM,饱和度未知) 的澄清溶液,此⽅案不适⽤于实验周期在半个⽉以上的实验。 以 1 mL ⼯作液为例,取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 900 μL ⽟⽶油中,混合均匀。

临床试验
科研文献
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
在线客服
咨询热线
400-881-9290
关注微信公众号