Ciprofloxacin monohydrochloride (Synonyms:盐酸环丙沙星; Bay-09867 monohydrochloride)
目录号 : KM12142 CAS No. : 93107-08-5 纯度 : 98%

Ciprofloxacin monohydrochloride (Bay-09867 monohydrochloride) 是一种氟喹诺酮类抗生素,具有高效的抗菌活性。

规格 价格 是否有货 数量
500mg
In-stock
1g
In-stock
5g
In-stock
10g 询价 In-stock
50g 询价 In-stock

Other Forms of Rapamycin:

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生物活性

Ciprofloxacin monohydrochloride (Bay-09867 monohydrochloride) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

体外研究

Ciprofloxacin monohydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. Ciprofloxacin monohydrochloride (CIP) shows potent activity against Y. pestis with MIC90 of 0.03 μg/mL.

体内研究

Ciprofloxacin monohydrochloride (1 mg/L) induces glutathione-S-transferase (GST) activity, in contrast with inhibited GST and Catalase (CAT) of larvae exposed to enrofloxacin. Ciprofloxacin monohydrochloride (≥10 μg/L) is ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae. In a murine model of pneumonic plague, Ciprofloxacin monohydrochloride (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in human following a 500 mg dose of oral Ciprofloxacin monohydrochloride. Intraperitoneal Ciprofloxacin monohydrochloride reduces the lung bacterial load compare to controls treated with intraperitoneal PBS.

分子式
C17H19ClFN3O3
分子量
367.80
CAS号
93107-08-5
中文名称
盐酸环丙沙星;环丙沙星盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*该产品在溶液状态不稳定,建议您现用现配,即刻使用。

溶解性数据
In Vitro: 

H2O : 12.5 mg/mL (33.99 mM; Need ultrasonic)

DMSO : 5 mg/mL (13.59 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7189 mL 13.5943 mL 27.1887 mL
5 mM 0.5438 mL 2.7189 mL 5.4377 mL
10 mM 0.2719 mL 1.3594 mL 2.7189 mL
*

请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液;该产品在溶液状态不稳定,建议您现用现配,即刻使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO → 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.5 mg/mL (1.36 mM); Clear solution

    此方案可获得 ≥ 0.5 mg/mL (1.36 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 5.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

     
  • 2.

    请依序添加每种溶剂: 10% DMSO → 90% corn oil

    Solubility: ≥ 0.5 mg/mL (1.36 mM); Clear solution

    此方案可获得 ≥ 0.5 mg/mL (1.36 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 5.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

临床试验
科研文献
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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