Procion Blue HB - CAS:12236-82-7

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Procion Blue HB (Synonyms:蓝色染料; Reactive Blue 2)

目录号 : KM12044 CAS No. : 12236-82-7

Data Sheet 产品使用指南

Procion Blue HB (Reactive Blue 2)是嘌呤能拮抗剂。

规格	价格	是否有货	数量
10mg		In-stock
50mg		In-stock
100mg		In-stock

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Ginkgolide K In-stock
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NH-3 In-stock
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生物活性

Procion Blue HB (Reactive Blue 2) is a purinergic antagonist.

体外研究

Reactive Blue 2 is used as an ATP receptor antagonist and induces Ca oscillations in HeLa cells. Reactive Blue 2 enhances a Ca response to histamine that is linked to the PLC cascade. Reactive Blue 2 may activate the PLC cascade in an extracellular Ca-dependent manner and induce Ca oscillations. The application of Reactive Blue 2 increases K secretion in a dose-dependent manner, and this increase is characterized as a peak followed by a partial relaxation to a steady-state. Reactive Blue 2 has antagonistic activities at P2Y4, and the antagonist potency at P2Y4 paralleled the potency of K+ secretion.The anthraquinone dye reactive blue 2 is found to be a potent inhibitor of a protein kinase isolated and purified from thylakoids. The mode of inhibition is noncompetitive, with a K_i of 8 μM for the membrane-bound kinase, and 6 microM for the purified kinase. The inhibitor does not modify the substrate preference of the endogenous kinase and could be removed from the membrane by washing. Reactive blue 2 selectively inhibits responses mediated via the P2ypurinoceptor, at least within a limited concentration range. In preparations where the tone has been raised with noradrenaline, ATP and 2-methylthio ATP, but not α,β-methylene ATP, produce relaxations of the vessel. These relaxations are inhibited in the presence of reactive blue 2. Reactive blue 2, at concentrations of 0.3-10 μM blocks the ATP-induced oscillation in a concentration-dependent manner.

分子式

C₂₉H₂₀N₇O₁₁S₃Cl

分子量

774.16

CAS号

12236-82-7

中文名称

蓝色染料；普施安蓝 HB；活性蓝 2；汽巴蓝 F3GA

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : ≥ 110 mg/mL (142.09 mM)

H₂O : 10 mg/mL (12.92 mM; Need ultrasonic)

Ethanol : < 1 mg/mL (insoluble)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.2917 mL	6.4586 mL	12.9172 mL
5 mM	0.2583 mL	1.2917 mL	2.5834 mL
10 mM	0.1292 mL	0.6459 mL	1.2917 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。