TML-6 - CAS:1462868-88-7

您当前的位置：

TML-6

目录号 : KM11390 CAS No. : 1462868-88-7 纯度 : 98%

Data Sheet 产品使用指南

TML-6 是一种口服有效的姜黄素衍生物，抑制 β-淀粉样前体蛋白和 β-淀粉样蛋白 (Aβ) 的合成。TML-6 上调 Apo E，抑制 NF-κB 和 mTOR，并增加抗氧化 Nrf2 基因的活性。TML-6 具有用于阿尔茨海默氏病 (AD) 研究的潜力。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

加入购物车大包装询价

Other Forms of Rapamycin:

Ginkgolide J In-stock
Ginkgolide K In-stock
THK-5470 In-stock
NH-3 In-stock
Velufenacin In-stock

KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。

生物活性

TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-oxidative Nrf2 gene. TML-6 has the potential for Alzheimer’s disease (AD) research.

体外研究

TML-6 (0.65-5.24 µg/mL; for 24 h) reduces the protein expression levels of APP and phospho-NF-κB, and induces the protein expression level of ApoE. TML-6 inhibits the mTOR signaling pathway through the suppression of phospho-mTOR.
TML-6 (0.31, 0.63, 2.5, 5, 10, 20 μM; 24 h) reveals no cytotoxicity in Huh-7 cells at concentrations below 5 μM and has an IC₅₀ of 4.19 µg/mL (8 μM).
TML-6 (1.05, 2.09, 3.14, 4.19 μg/mL; 24 h) reduces the production of Aβ40 and Aβ42 between 1.05, 2.09 and 3.14 μg/mL (equal to 2, 4 and 6 μM) in a dose-dependent manner in N2a/APPswe cell.
TML-6 can exhibit transcriptional activation of the Nrf2 gene in a dose-dependent manner, with the highest activity at a concentration of 1.32 µg/mL.

Western Blot Analysis

Cell Line:	Huh-7 cells
Concentration:	0.65, 1.31, 1.96, 2.61, 3.93, 5.24 µg/mL
Incubation Time:	For 24 hours
Result:	Reduced the amyloid precursor protein (APP) protein expression level by 60% and decreased the level of phosphorylated NF-κB by about 50% at a dose of 1.96 µg/mL after 24 h treatment. Induced the protein expression level of ApoE by approximately 44% at a dose of 2.62 µg/mL.

体内研究

TML-6 (diet; 150 mg/kg/day; for four months) treatment results in significant improvement in learning, suppression of the microglial activation marker Iba-1, and reduction in Aβ in the brain.
TML-6 (oral; 150 mg/kg) has a T_1/2 of 1.27 hours, a C_max of 35.9 ng/mL and an AUC of 177 ng•hr/mL.

Animal Model:	Six-month-old 3xTg (mutations: APP_KM670/671NL, MAPT_P301L and PSEN1_M146V) AD transgenic mice
Dosage:	150 mg/kg
Administration:	Diet; daily; for four months
Result:	Improved the learning behaviors, significantly suppressed the Aβ levels and Iba-1 expression in the brain of 3xTg AD transgenic mice.

Animal Model:	SD rats
Dosage:	150 mg/kg (Pharmacokinetic Analysis)
Administration:	Oral
Result:	Had a T_1/2 of 1.27 hours, a C_max of 35.9 ng/mL and an AUC of 177 ng•hr/mL.

分子式

C₃₀H₃₇NO₇

分子量

523.62

CAS号

1462868-88-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据

In Vitro:

DMSO : 120 mg/mL (229.17 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9098 mL	9.5489 mL	19.0978 mL
5 mM	0.3820 mL	1.9098 mL	3.8196 mL
10 mM	0.1910 mL	0.9549 mL	1.9098 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%