Bafilomycin C1 - CAS:88979-61-7

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Bafilomycin C1 (Synonyms:巴菲霉素C1)

目录号 : KM11350 CAS No. : 88979-61-7

Data Sheet 产品使用指南

Bafilomycin C1 是从链霉菌中分离得到的大环内酯类抗生素 (antibiotic)。Bafilomycin C1 是一种有效的、特异性的、可逆的 vacuolar-type H⁺-ATPases 抑制剂。Bafilomycin C1 抑制革兰氏阳性菌 (bacteria) 和真菌 (fungi) 的生长。Bafilomycin C1 可诱导细胞凋亡 (apoptosis)，可用于肝细胞癌 (HCC) 的研究。

规格	价格	是否有货	数量
500μg		In-stock
1mg		In-stock

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生物活性

Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi. Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC).

体外研究

Bafilomycin C1 (0.33-10 μM; 6 days) inhibits the growth and proliferation of SMMC7721 and HepG2 cells in a timeand dose-dependent manner.
Bafilomycin C1 (0.33-3.3 μM; 24 hours) decreases cyclin D3, cyclin E1, CDK2, CDK4, and CDK6 expression in both mRNA and protein expression in SMMC7721 cells.
Bafilomycin C1 (3.3-10 μM; 24 hours) causes morphological alterations and increases the population of apoptotic cells by Hoechst 33258 staining compared to vehicle.

Cell Viability Assay

Cell Line:	SMMC7721 cell and HepG2 cell
Concentration:	0.33 μM, 1.1 μM, and 3.3 μM for SMMC7721 1.1 μM, 3.3 μM, and 10.0 μM for HepG2
Incubation Time:	6 days
Result:	Retarded the cell growth.

Western Blot Analysis

Cell Line:	SMMC7721 cells
Concentration:	3.3 μM
Incubation Time:	24 hours
Result:	Decreaed cyclin D3/E1,CDK2/4/6 protein expression and increased p21.

Apoptosis Analysis

Cell Line:	SMMC7721 and HepG2 cells
Concentration:	3.3 μM; 10 μM
Incubation Time:	24 hours
Result:	Induced apoptosis in SMMC7721 and HepG2 cells.

体内研究

Bafilomycin C1 (subcutaneous injection; 0.2 mg/kg; 20 days) retards the tumor growth without apparent adverse reactions or side effects in nude mice model.

Animal Model:	BALB/c nude mice (weighing 18-20 g) subcutaneous injected by SMMC7721 cell suspension (5×10 cells/100 μL)
Dosage:	0.2 mg/kg
Administration:	Subcutaneous injection; 20 days
Result:	Suppressed tumor growth of SMMC7721 tumor xenografts.

分子式

C₃₉H₆₀O₁₂

分子量

720.89

CAS号

88979-61-7

中文名称

巴菲霉素C1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据

In Vivo:

1.

Bafilomycin C1 (0.2 mg/kg body weight, dissolved in 60% 1,2-propanediol)

Data Sheet

产品使用指南

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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Other Forms of Rapamycin:

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