Cl-NQTrp - CAS:185351-23-9

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Cl-NQTrp

目录号 : KM10978 CAS No. : 185351-23-9

Data Sheet 产品使用指南

Cl-NQTrp 显著破坏 tau 衍生的 PHF6 (VQIVYK) 肽和全长 tau 蛋白的预制纤维聚集物。

规格	价格	是否有货	数量
5mg		In-stock
10mg		In-stock
25mg		In-stock
50mg		In-stock
100mg		In-stock

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生物活性

Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein.

体外研究

Cl-NQTrp efciently disassembled pre-formed PHF6 peptide fbrils.
Cl-NQTrp has the potential to induce conformational changes in PHF6 peptide oligomers.

体内研究

Cl-NQTrp could be a unique potential therapeutic for AD since it targets aggregation of both Aβ and tau.
Cl-NQTrp significantly alleviates the shorter life span of htau-expressing flies, leading to 58% viability on day 29.

Animal Model:	Virgin females, carrying either the eye GMR -Gal4 driver or the pan-neuronal driver elav -Gal4 on chromosome X, were collected and crossed with males carrying UAS-h tau on the 2nd chromosome or with wild-type Oregon-R (OR) males as a control.
Dosage:	0.75 mg/mL.
Administration:	Dripped every other day.
Result:	Inhibited PHF6 aggregation and ameliorates eye neurodegeneration Drosophila overexpressing the human tau protein (htau).

分子式

C₂₁H₁₅N₂O₄Cl

分子量

394.81

CAS号

185351-23-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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