Lipoxin A4 - CAS:89663-86-5

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Lipoxin A4 (Synonyms:脂氧素 A4; LXA4)

目录号 : KM10744 CAS No. : 89663-86-5

Data Sheet 产品使用指南

Lipoxin A4 (LXA4) 是一种内源性脂氧合酶衍生的类二十烷酸调节剂，具有强大的抗炎和促消炎双重特性。Lipoxin A4 抑制与 ERK1/2 和 NF-kB 通路相关的人表皮角质形成细胞 (NHEK) 的增殖以及炎性细胞因子/趋化因子(如IL-6，IL-8等)的产生。Lipoxin A4 抑制血清淀粉样蛋白 A (SAA) 介导的 IL-8 释放，IC₅₀ 值为 25.74 nM。

规格	价格	是否有货	数量
25μg		In-stock

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生物活性

Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC₅₀ value of 25.74 nM.

体外研究

Lipoxin A4 (LXA4) inhibits the expression of IL-6 and IL-8 in NHEKs.
Lipoxin A4 downregulates the expression of cyclin D1.
Lipoxin A4 also suppresses the ERK1/2 phosphorylation and NF-kB-p65 nuclear translocation of NHEKs.
LXA4 (100 nM; preincubation for 30 minutes)inhibits the proliferation of NHEKs with or without stimulating by LPS (10 μg/mL).
LXA4 pretreatment (100 nM for 30 minutes) downregulates the LPS-induced secretion and expression of HMGB1 in keratinocytes.

Cell Proliferation Assay

Cell Line:	Normal human epidermal keratinocytes (NHEKs)
Concentration:	100 nM
Incubation Time:	30 minutes
Result:	A significant increase in proliferation of NHEKs after 7 days of stimulation with LPS (10 μg/mL) was seen. However, there was a significant decrease in the proliferation of NHEKs when pretreated with LXA4 for 30 min.

Western Blot Analysis

Cell Line:	Normal human epidermal keratinocytes (NHEKs)
Concentration:	100 nM
Incubation Time:	30 minutes.
Result:	HMGB1 protein levels in the cytoplasm of NHEKs were induced by LPS, which were decreased after preincubation with LXA4 but decreased in the nucleus after stimulation with LPS.

分子式

C₂₀H₃₂O₅

分子量

352.47

CAS号

89663-86-5

中文名称

脂氧素 A4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet

产品使用指南

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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