L-Canaline 是存在于许多豆科植物中的一种非蛋白质氨基酸。L-Canaline 是 L-canavanine 及其精氨酸酶催化的毒性代谢产物。L-Canaline 是一种有效且不可逆的鸟氨酸氨基转移酶抑制剂。L-Canaline 抑制疟原虫恶性疟原虫的生长，IC50 为 297 nM。L-Canaline 具有抗癌和抗增殖作用。
| 生物活性 |
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. L-Canaline has anticancer and antiproliferative effects. |
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| 体外研究 |
L-Canaline treatment inhibits the proliferation of PBMCs after stimulation by phorbol 12-myristate-13-acetate (PMA) or via the mixed lymphocyte reaction. The greatest effect is seen with PMA-stimulated cells, where L-canaline has an IC50 of 0.26 mM. L-Canaline is slightly less toxic to PBMCs stimulated via the mixed lymphocyte reaction (IC50 of 0.54 mM).
L-canaline inhibits L-lysine flux competitively (Ki of 4.6 mM) in astrocytes and astrocytoma cells. |
| 体内研究 |
L-Canaline decreases the aspartic acid content of tissues of the medulla oblongata of male Wistar rats, but it does not affect the evoked release of this nonprotein amino acid into these tissues.
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| 分子式 |
C4H10N2O3
|
| 分子量 |
134.13
|
| CAS号 |
496-93-5
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
客服小K 
客服小K
Data Sheet
