Nicotinamide riboside chloride - CAS:23111-00-4

您当前的位置：

Nicotinamide riboside chloride (Synonyms:烟酰胺核糖氯酸盐)

目录号 : KM10301 CAS No. : 23111-00-4 纯度 : 98%

Data Sheet 产品使用指南

Nicotinamide riboside Chloride 是具有口服活性的 NAD⁺ 的前体，增加 NAD⁺ 水平并激活 SIRT1 和 SIRT3。Nicotinamide riboside Chloride 是维生素 B3 (烟酸) 的来源，可以增强氧化代谢并防止高脂肪饮食诱导的代谢异常。Nicotinamide riboside Chloride 可以减少阿尔茨海默氏病转基因小鼠模型中的认知退化。

规格	价格	是否有货
100mg		In-stock
200mg	询价	In-stock
500mg	询价	In-stock

加入购物车大包装询价

Other Forms of Rapamycin:

Ginkgolide C In-stock
RP 70676 In-stock
Heptasaccharide Glc4Xyl3 In-stock
Fructo-oligosaccharide DP12/GF11 In-stock
6-Hydroxypyridin-2(1H)-one hydrochloride In-stock

KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。

生物活性

Nicotinamide riboside Chloride, an orally active NAD precursor, increases NAD levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.

体外研究

Nicotinamide riboside Chloride (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2.
Nicotinamide riboside Chloride increases intracellular and mitochondrial NAD content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM.
Nicotinamide riboside chloride boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19.

Western Blot Analysis

Cell Line:	HEK293T cells
Concentration:	0.5 nM
Incubation Time:	24 hours
Result:	Reduced the acetylation status of Ndufa9 and SOD2.

体内研究

Chronic Nicotinamide riboside Chloride (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD content in a tissue-specific manner.

Animal Model:	10-week-old C57Bl/6J mice
Dosage:	400 mg/kg
Administration:	PO; daily; for 16 weeks
Result:	Increased plasma and intracellular NAD content in a tissue-specific manner.

分子式

C₁₁H₁₅ClN₂O₅

分子量

290.70

CAS号

23111-00-4

中文名称

烟酰胺核糖氯酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

H₂O : 125 mg/mL (430.00 mM; Need ultrasonic)

DMSO : 50 mg/mL (172.00 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.4400 mL	17.1999 mL	34.3997 mL
5 mM	0.6880 mL	3.4400 mL	6.8799 mL
10 mM	0.3440 mL	1.7200 mL	3.4400 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

临床试验

科研文献