BAY 73-6691 - CAS:794568-92-6

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BAY 73-6691 (Synonyms:(R-BAY 73-6691))

目录号 : KM9405 CAS No. : 794568-92-6 纯度 : 98%

Data Sheet 产品使用指南

BAY 73-6691 ((R)-BAY 73-6691) 是一种有效的，可透过血脑屏障的选择性 PDE9A 抑制剂。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
25mg		In-stock
50mg		In-stock
100mg		In-stock
200mg	询价	In-stock
500mg	询价	In-stock

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生物活性

BAY 73-6691 ((R)-BAY 73-6691) is a potent, brain penetrant, and selective PDE9A inhibitor.

体外研究

The BAY 73-6691 dose-dependently alleviates cell viability loss due to Aβ_25-35 treatment. It is found that when SH-SY5Y cells are cultured by Aβ_25-35, a high degree of cell apoptosis is observed, while additional stimulation with BAY 73-6691 causes attenuation of cell apoptosis. BAY 73-6691 dose-dependently attenuates oxidative stress induced by Aβ_25-35, and BAY 73-6691 at 200 μg/mL almost neutralizes Aβ_25-35-induced oxidative damage. The BAY 73-6691 attenuates Aβ_25-35-induced increase of apoptosis cells.

体内研究

BAY 73-6691 dose-dependently improves the acquisition performance in the Aβ_25-35-injected mice on days 7 to 10 (day 7, F_(5,54)=65.153; day 8, F_(5,54)=62.340; day 9, F_(5,54)=37.529; day 10, F_(5,54)=38.624; P<0.001). BAY 73-6691 at 3 mg/kg can almost completely abolish the prolongation of escape-latency on days 9 to 10. BAY 73-6691 dose-dependently elevates the Aβ_25-35-induced decrease of the dwell time on the 10th day post Aβ_25-35 injection (day 10, F_(5,54)=27.360, P<0.001). Results reveal that the Aβ_25-35 injection and BAY 73-6691 treatment cause no influence on the swimming speed. Treatment with BAY 73-6691 does not cause detectable alteration of spatial memory in sham mice. BAY 73-6691 alleviates Aβ_25-35-induced abnormalities of the above indices. The BAY 73-6691 causes no influence on the four indices mentioned above in sham mice. The BAY 73-6691 has no significant effect on the apoptosis of hippocampal neurons in sham mice.

分子式

C₁₅H₁₂N₄OF₃Cl

分子量

356.73

CAS号

794568-92-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 160 mg/mL (448.52 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8032 mL	14.0162 mL	28.0324 mL
5 mM	0.5606 mL	2.8032 mL	5.6065 mL
10 mM	0.2803 mL	1.4016 mL	2.8032 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: 2.5 mg/mL (7.01 mM); Suspended solution; Need ultrasonic

此方案可获得 2.5 mg/mL (7.01 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (7.01 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.01 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。