Nonactin 来源于 Streptomyces griseus， 是一种抗生素，作为 K+ 和 NH4+ 载体。Nonactin 是一种氧化磷酸化 (OXPHOS) 解偶联剂。Nonactin 选择性诱导含突变 β-catenin 的细胞凋亡。Nonactin 抑制内源性 HSP60 表面表达。
| 生物活性 |
Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K, and NH4. Nonactin is able to uncouple the oxidative phosphorylation (OXPHOS) of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin. Nonactin inhibits the surface expression of endogenous HSP60. |
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| 分子式 |
C40H64O12
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| 分子量 |
736.93
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| CAS号 |
6833-84-7
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| 中文名称 |
无活菌素
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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纯度： ≥95%
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