Human oxidized low density lipoprotein (ox-LDL) 是一种关键的促动脉粥样硬化信号调节剂和凋亡诱导剂。它通过结合 TLR4 及 SR-A、CD36、LOX-1 等清道夫受体介导细胞摄取与信号传导，并定位于动脉粥样硬化病变部位。在凋亡调控方面，ox-LDL 通过配体依赖性的 Fas 受体通路及共激活的 TNF 受体 I/II 介导凋亡活性，诱导 Caspase 2、3、6、8 活性亚基形成，同时上调促凋亡蛋白 Bad、下调抗凋亡蛋白 Bcl-2，发挥细胞毒性作用。此外，ox-LDL 还可激活 MAPK、NFκB、p53 及 AP-1 等多种信号通路，诱导泡沫细胞形成和单核细胞趋化，刺激血管细胞增殖、细胞因子产生及血小板活化，同时抑制内皮依赖性血管舒张。该分子可用于动脉粥样硬化的相关研究。
| 生物活性 |
Oxidized low density lipoprotein (Human) (Human ox-LDL) is a key pro-atherosclerotic signal regulator and apoptosis inducer. Oxidized low density lipoprotein (Human) mediates cellular uptake and signal transduction by binding to TLR4 and scavenger receptors such as SR-A, CD36, LOX-1, and localizes to atherosclerotic lesion sites. Oxidized low density lipoprotein (Human) mediates Apoptosis activity through the ligand-dependent Fas receptor pathway and co-activated TNF receptors I/II, induces the formation of active subunits of Caspase 2, 3, 6, 8, and simultaneously activates multiple signaling pathways including MAPK, NFκB, p53 and AP-1 complexes. Oxidized low density lipoprotein (Human) exerts cytotoxicity by upregulating the pro-apoptotic protein Bad and downregulating the level of the anti-apoptotic protein Bcl-2, inducing foam cell formation and monocyte chemotaxis. Oxidized low density lipoprotein (Human) also stimulates vascular cell proliferation, cytokine production and platelet activation, while inhibiting endothelium-dependent vasodilation. Oxidized low density lipoprotein (Human) can be used in atherosclerosis-related research. |
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| 体外研究 |
Oxidized low density lipoprotein (Human) (200 μg/mL; 24 h) 可激活Caspase 2、3、6、8； Oxidized low density lipoprotein (Human) (200 μg/mL; 24 h) 可激活NF-κB、AP-1；升高p53、ATF-2、ELK-1、CREB. |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Store at 2-8°C for 20 weeks, avoid freeze.
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纯度： 98%
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